Abstract: The Programs Of multi-collectors for measurements of Nd, Sr concentrations and isotopic ratios were designed according to two schemes of single-double and double-single calibrations. High precision data can be obtained during one measurement, ~(146)Nd was used for Nd determinations, which isotopic ratios were normalized with parameters of~(145)Nd/~(144)Nd=0.348430 and ~(146)Nd/~(144)Nd=2.07188.The analysis runs 4 or 5 collectors in which Axial collector jump at mass of 144, 145 and 150.5.The average ~(143)Nd/~(144)Nd of La Jolla Standard for fifteen beads is 0.511844±0.000005(2σ).The rock standard of BCR-1 yield ~(143)Nd/~(144)Nd=0.512634±0.000006(2σ) and Nd concentration is 29.22ppm. Sr analysis uses 3 or 4 collectors and Axial collector jump at mass of 86, 87, 88 and 91.5. Data calculations are similar to Nd program.