Abstract: By the use of laser desorption/ionization mass spectrometry fullerenes were analyzed with very high sensitivity(better than 2 femtomol). Under laser radiatioo the fragmentaion path of C60and C70 were investigated. Mixture of fullerenea were analed with satisfied results. The results demonstrated that laser desorption/ionization time-of-flight mass spectrometry is a powerful tool for the investigation of fullerenes.