气相色谱-质谱联用法检测保健品中4种PDE-5抑制剂药物

Detection of Four PDE-5 Inhibitors in Nutriment Products by GC/MS

摘要: 采用气相色谱质谱联用法同时检测保健品中的他达那非（tadalafil），西地那非（sildenafil），好猫西地那非（homosildenafil），伐地那非（vardenafil）。用乙酸乙酯提取，HP-1MS色谱柱(17 m ×0.2 mm×0.11 mm )分离，程序升温，质谱检测。该方法的检测限能满足保健品日常检测的要求，前处理简单、快速、可靠。

Abstract: Total of 4 PDE-5 inhibitors (tadalafil, sildenafil, homosildenafil, vardenafil) were simultaneously detected by gas chromatography-mass spectrometry coupling with electronic ionization. The sample was extracted with the ethyl acetate and completely separated by HP-1MS column (17m ×0.2 mm×0.11mm) in linear temperature program. The method is simple, rapid and reliable. It is suitable for screening PDE-5 inhibitors in routine analysis for nutriment products.