Analysis of Typical Cyclic Imine Toxins by Atmospheric Pressure Chemical Ionization-Mass Spectrometry

WANG Yan-long; CHEN Jun-hui; LI Zhao-yong; WANG Shuai; ZHEN Xiao-ling; WANG Xiao-ru

doi:10.7538/zpxb.youxian.2015.0028

Journal of Chinese Mass Spectrometry Society > 2015 > 36(6): 551-558. > DOI: 10.7538/zpxb.youxian.2015.0028 CSTR: 32365.14.zpxb.youxian.2015.0028

WANG Yan-long, CHEN Jun-hui, LI Zhao-yong, WANG Shuai, ZHEN Xiao-ling, WANG Xiao-ru. Analysis of Typical Cyclic Imine Toxins by Atmospheric Pressure Chemical Ionization-Mass Spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2015, 36(6): 551-558. DOI: 10.7538/zpxb.youxian.2015.0028

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Analysis of Typical Cyclic Imine Toxins by Atmospheric Pressure Chemical Ionization-Mass Spectrometry

1.
Research Center for Marine Ecology, The First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China
2.
Xiamen Huaxia Vocational College, Xiamen 361024, China

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Abstract

The fragmentation characteristics of two typical cyclic imine toxins (GYM and SPX1) were analyzed by ion trap-atmospheric pressure chemical ionization-mass spectrometry (IT-APCI-MS). The results showed that quasi-molecular ion peak[M+H]⁺ (base peak) of GYM and SPX1 was detected by APCI-MS. Stability characteristic fragment ions were observed by the neutral loss of H₂O from precursor ions [M+H]⁺ for APCI-MS². Then, the fragmentation pathways of GYM and SPX1 were discussed based on APCI-MS³ analysis. Based on the comparison of two methods, the sensitivity of APCI-MS is better than ESI-MS for analysis of GYM and SPX1. The matrix interference resistance, specificity, repeatability and stability of the LC-APCI-MS² method are better than LC-ESI-MS² method for analysis of GYM and SPX1 in four different matix. In conclusion, APCI-MS is suitable for determination of cyclic imine toxins, and this study can provide a good reference and basis for qualitative and quantitative analysis of cyclic imine toxins in different complex matrix samples by LC-APCI-MS.

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