Application and Development of Quadrupole Electrode System in Mass Spectrometry

XU Fu-xing; YANG Kai; WANG Qiang; ZHAO Xin; CHEN Bin; DING Chuan-fan

doi:10.7538/zpxb.youxian.2015.0040

Journal of Chinese Mass Spectrometry Society > 2015 > 36(6): 481-491. > DOI: 10.7538/zpxb.youxian.2015.0040 CSTR: 32365.14.zpxb.youxian.2015.0040

XU Fu-xing, YANG Kai, WANG Qiang, ZHAO Xin, CHEN Bin, DING Chuan-fan. Application and Development of Quadrupole Electrode System in Mass Spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2015, 36(6): 481-491. DOI: 10.7538/zpxb.youxian.2015.0040

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Application and Development of Quadrupole Electrode System in Mass Spectrometry

1.
Department of Chemistry, Fudan University, Shanghai 200433, China
2.
China National Environment Monitoring Center, Beijing 100012, China

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Abstract

The linear quadrupole rodset has become a very important scientific instrument which can be used to produce quadrupolar electric field distribution. Because of the special property of ion motion in the linear quadrupole system, it has been widely used to build quadrupole mass filter, linear ion trap, quadrupole ion guide and many linear quadrupole related tandem mass spectrometer. All of these equipments have become an essential chemical and biological analytical technique with numerous applications in many fields, such as bioscience, chemistry, geology, environment, food safety and so on. In this paper, the theory of the linear quadrupole was briefly reviewed, including the kinetics of ion motion in quadrupole field, the effect of rodset structure on the field distribution, the effects of higher order electric field on the property of mass analysis and ion transmission. Then the latest research results in the field of quadrupole mass analyzer and quadrupole ion trap mass spectrometry were introduced. On the basis of this, the research direction of the quadrupole electrode system is prospected.
- linear quadrupole,
- mass filter,
- linear ion trap,
- mass resolution,
- ion guide

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[1]	PAUL W, RAETHER H P, von ZAHN U. Das elektrische massenfilter als massenspektrometer und isotopentrenner[J]. Zeit Schrift Fur Puysik, 1958, 152(2): 143-182.
[2]	BRUBAKER W M. Improved quadrupole mass filter[J]. Journal of Vacuum Science & Technology,1966, 3(5): 305.
[3]	DU Z, DOUGLAS D J, KONENKOV N. Peak splitting with a quadrupole mass filter operated in the second stability region[J]. Journal of the American Society for Mass Spectrometry, 1999, 10(11): 1262-1270.
[4]	DING L, SUDAKOV M, KUMASHIRO S. A simulation study of the digital ion trap mass spectrometer[J]. International Journal of Mass Spectrometry, 2002, 221(2): 117-138.
[5]	WANG L, XU F X, DING C F. Performance and geometry optimization of the ceramic-based rectilinear ion trap[J]. Rapid Communications in Mass Spectrometry, 2012, 26(17): 2068-2074.
[6]	SONG Q Y, KOTHARI S, SENKO M A, et al. Rectilinear ion trap mass spectrometer with atmospheric pressure interface and electrospray ionization source[J]. Anal Chem, 2006, 78(3): 718-725.
[7]	DOUGLAS D J. Linear Quadrupoles in mass spectrometry[J]. Mass Spectrometry Reviews, 2009, 28(6): 937-960.
[8]	DAWSON, PETER H. Quadrupole mass spectrometry and its applications[M]. Amsterdam: Elsivier Scientific Publishing Compay, 1976: 1-151.
[9]	DOUGLAS D J, FRENCH J B. Collisional focusing effects in radio frequency quadrupoles[J]. Journal of the American Society for Mass Spectrometry, 1992, 3(4): 398-408.
[10]	WELLS J M, MCLUCKEY S A. Collision-induced dissociation (CID) of peptides and proteins[J]. Biological Mass Spectrometry, 2005, 402: 148-185
[11]	DU Z, DOUGLAS D J. A novel tandem quadrupole mass analyzer[J]. Journal of the American Society for Mass Spectrometry, 1999, 10(11): 1053-1066.
[12]	AUSTIN W E, LECK J H, BATEY J H. Study of the performance of a group of quadrupole mass spectrometry[J]. Journal of Vacuum Science & Technology A-Vacuum Surfaces and Films, 1992, 10(6):3563-3567.
[13]	KONENKOV N. Influence of fringing fields on the acceptance of a quadrupole mass filter operated in the separation mode of the intermediate stability region[J]. Int J Mass Spectrom Ion Proc, 1993, 123(2): 101-105.
[14]	DENISON D R. Operating parameters of a quadrupole in a grounded cylindrical housing[J]. Journal of Vacuum Science & Technology, 1971, 8(1): 266-269.
[15]	LOURIS J N, COOKS R G, SYKA J E P, et al. Instrumentation, applications and energy deposition in quadrupole ion-trap tandem mass-spectrometry[J]. Analytical Chemistry, 1987, 59(13): 1677-1685.
[16]	MCLUCKEY S A. Principles of collisional activation in analytical mass spectrometry[J]. Journal of the American Society for Mass Spectrometry, 1992, 3(6): 599-614.
[17]	DENG L, KITOVA E N, KLASSEN J S. Mapping protein-ligand interactions in the gas phase using a functional group replacement strategy. Comparison of CID and BIRD activation methods[J]. Journal of the American Society for Mass Spectrometry, 2013, 24(5): 988-996.
[18]	LONDRY F A, WELLS G J, MARCH R E. Enhanced mass resolution in a quadrupole ion trap[J]. Rapid Communications in Mass Spectrometry, 1993, 7(1): 43-45.
[19]	STEPHENSON J L, BOOTH M M, SHALOSKY J A, et al. Infrared multiple-photon dissociation in the quadrupole-ion-trap via a multipass optical arrangement[J]. Journal of the American Society for Mass Spectrometry, 1994, 5(10): 886-893.
[20]	DING C, KONENKOV N, DOUGLAS D J. Quadrupole mass filters with octopole fields[J]. Rapid Communications in Mass Spectrometry, 2003, 17(22): 2495-2502.
[21]	DOUGLAS D J, GLEBOVA T A, KONENKOV N V, et al. Spatial harmonics of the field in a quadrupole mass filter with circular electrodes[J]. Technical Physics, 1999, 44(10): 1215-1219.
[22]	KONENKOV N V, SUDAKOV M, DOUGLAS D J. Matrix methods for the calculation of stability diagrams in quadrupole mass spectrometry[J]. Journal of the American Society for Mass Spectrometry, 2002, 13(6): 597-613.
[23]	DAYTON I E, SHOEMAKER F C, MOZLEY R F. The measurement of two-dimensional fields. Part II: study of a quadrupole magnet[J]. Review of Scientific Instruments, 1954, 25(5): 485-489.
[24]	LEE-WHITING G E, YAMAZAKI L. Semi analytical calculations for circular quadrupoles[J]. Nuclear Instruments and Methods, 1971, 94(2): 319-332.
[25]	REUBEN A J, RADCHIK A V, SMITH G B, et al. Exact fields in multi-electrode ion optics[J]. Rapid Communications in Mass Spectrometry, 1994, 8(12): 939-941.
[26]	SCHULTE J, SHEVCHENKO P V, RADCHIK A V. Nonlinear field effects in quadrupole mass filters[J]. Review of Scientific Instruments, 1999, 70(9): 3566-3571.
[27]	GIBSON J R, TAYLOR S. Prediction of quadrupole mass filter performance for hyperbolic and circular cross section electrodes[J]. Rapid Communications in Mass Spectrometry, 2000, 14(18): 1669-1673.
[28]	GIBSON J R, TAYLOR S. Numerical investigation of the effect of electrode size on the behaviour of quadrupole mass filters[J]. Rapid Communications in Mass Spectrometry, 2001, 15(20): 1960-1964.
[29]	KONENKOV N, LONDRY F, DING C F, et al. Linear quadrupoles with added hexapole fields[J]. Journal of the American Society for Mass Spectrometry, 2006, 17(8): 1063-1073.
[30]	ZHAO X Z, Xiao Z L, Douglas D J. Overcoming field imperfections of quadrupole mass filters with mass analysis in islands of stability[J]. Anal Chem, 2009, 81(14): 5806-5811.
[31]	SUDAKOV M, DOUGLAS D J. Linear quadrupoles with added octopole fields[J]. Rapid Communications in Mass Spectrometry, 2003, 17(20): 2290-2294.
[32]	KONENKOV N, ZHAO X Z, XIAO Z, et al. Mass analysis in islands of stability with linear quadrupoles with added octopole fields[J]. Journal of the American Society for Mass Spectrometry, 2007, 18(5): 826-834.
[33]	MORADIAN A, DOUGLAS D J. Mass selective axial ion ejection from linear quadrupoles with added octopole fields[J]. Journal of the American Society for Mass Spectrometry, 2008, 19(2): 270-280.

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