Progress on Electrostatic Orbitrap Mass Spectrometer

Electrostatic orbitrap is anewly developing mass analyzer in recent years. The information of ions inorbitrap can be obtained based on the different motion frequency of differentions in a specific electrostatic field. Orbitrap mass analyzer has theadvantages of high mass resolution and high mass accuracy, therefore it hasbeen widely used in chemistry, biology, medicine, et al. In this paper，the principle of electrostatic orbitrap massspectrometer was introduced in detail； the applications of orbitrap in the fields ofproteomics and metabolomics were briefly discussed； the recent progresses of coupling orbitrap withambient ionization techniques were reviewed. Coupling orbitrap with ambientionization techniques such as extractive electrospray ionization (EESI), lowtemperature probe (LTP) can potentially used for protein analysis, directidentification of product in the chemical synthesis, the study of mechanism ofchemical reaction.