Citation: | ZHAO Ming-yue, HOU Yu-zhu, LIU Xin, WANG Yang, SUN Kai-ju, PANG Bo, LIU Shu-ying, LI Dan, SU Rui. Metabolomics of Mice Serum Analysis to Assess the Effects of Saikosaponin D on Breast Cancer[J]. Journal of Chinese Mass Spectrometry Society, 2022, 43(2): 142-154. DOI: 10.7538/zpxb.2021.0084 |
[1] |
SUNG H, FERLAY J, SIEGEL R L, LAVERSANNE M, SOERJOMATARAM I, JEMAL A, BRAY F. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2021, 71(3): 209-249.
|
[2] |
YIN Y, WANG X, LI T, REN Q, LI L, SUN X, ZHANG B, WANG X, HAN H, HE Y, CAO Z, SUN X, ZHOU Z. MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling[J]. Cancer Medicine, 2020, 9(4): 1544-1552.
|
[3] |
ECHEVERRIA G V, GE Z, SETH S, ZHANG X, JETER-JONES S, ZHOU X, CAI S, TU Y, MCCOY A, PEOPLES M, SUN Y, QIU H, CHANG Q, BRISTOW C, CARUGO A, SHAO J, MA X, HARRIS A, MUNDI P, LAU R, RAMAMOORTHY V, WU Y, ALVAREZ M J, CALIFANO A, MOULDER S L, SYMMANS W F, MARSZALEK J R, HEFFERNAN T P, CHANG J T, PIWNICA-WORMS H. Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state[J]. Science Translational Medicine, 2019, 11(488): eaav0936.
|
[4] |
XIANG S, DAUCHY R T, HAUCH A, MAO L, YUAN L, WREN M A, BELANCIO V P, MONDAL D, FRASCH T, BLASK D E, HILL S M. Doxorubicin resistance in breast cancer is driven by light at nightinduced disruption of the circadian melatonin signal[J]. Journal of Pineal Research, 2015, 59(1): 60-69.
|
[5] |
HONG J, HUANG J, SHEN L, ZHU S, GAO W, WU J, HUANG O, HE J, ZHU L, CHEN W, LI Y, CHEN X, SHEN K. A prospective, randomized study of toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis[J]. BMC Cancer, 2020, 20(1): 663.
|
[6] |
JEON J, KIM S E, LEE D Y, CHOI D. Factors associated with endometrial pathology during tamoxifen therapy in women with breast cancer: a retrospective analysis of 821 biopsies[J]. Breast Cancer Research and Treatment, 2020, 179(1): 125-130.
|
[7] |
KESHAVARZI Z, JANGHORBAN R, ALIPOUR S, TAHMASEBI S, JOKAR A. The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer[J]. Supportive Care in Cancer, 2019, 27(4): 1325-1334.
|
[8] |
NELSON H D, FU R, ZAKHER B, PAPPAS M, MCDONAGH M. Medication use for the risk reduction of primary breast cancer in women[J]. Jama-Journal of the American Medical Association, 2019, 322(9): 868-886.
|
[9] |
BELTRAME D, di SALLE E, GIAVINI E, GUNNARSSON K, BRUGHERA M. Reproductive toxicity of exemestane, an antitumoral aromatase inactivator, in rats and rabbits[J]. Reproductive Toxicology, 2001, 15(2): 195-213.
|
[10] |
GOSS P E, INGLE J N, PRITCHARD K I, ELLIS M J, SLEDGE G W, BUDD G T, RABAGLIO M, ANSARI R H, JOHNSON D B, TOZER R, D′SOUZA D P, CHALCHAL H, SPADAFORA S, STEARNS V, PEREZ E A, LIEDKE P E, LANG I, ELLIOTT C, GELMON K A, CHAPMAN J A, SHEPHERD L E. Exemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA. 27a randomized controlled phase Ⅲ trial[J]. Journal of Clinical Oncology, 2013, 31(11): 1398-1404.
|
[11] |
LI X, LI Y, GONG W, YANG M Y, YANG Y, LI Z P, WANG Y L, ZHANG Z Q. Auto-induction effect of chloroxoquinoline on the cytochrome P450 enzymes of rats associated with CYP 3A and 1A[J]. PLoS One, 2015, 10(9): e0138875.
|
[12] |
李莉,李根,陈力,伍丽萍,郭文玫,陶婉君. 基于美国FDA不良事件报告系统数据库的来曲唑风险信号挖掘[J]. 药物不良反应杂志,2020,22(9):511-517.
LI Li, LI Gen, CHEN Li, WU Liping, GUO Wenmei, TAO Wanjun. Study on the risk signal mining related to letrozole based on the US Food and drug administration adverse event reporting system[J]. Adverse Drug Reactions Journal, 2020, 22(9): 511-517(in Chinese). |
[13] |
申晓倩,张文东,何源流,丛晓,苏国海,郝恩魁. 曲妥珠单抗诱导大鼠心功能降低及其机制的探讨[J]. 山东大学学报(医学版),2013,51(12):11-14,40.
SHEN Xiaoqian, ZHANG Wendong, HE Yuanliu, CONG Xiao, SU Guohai, HAO Enkui. Research on cardiac dysfunction induced by trastuzumab and the possible mechanisms[J]. Journal of Shandong University (Health Sciences), 2013, 51(12): 11-14, 40(in Chinese). |
[14] |
VAHID B, MEHROTRA A. Trastuzumab (herceptin)-associated lung injury[J]. Respirology, 2006, 11(5): 655-658.
|
[15] |
文秀英,张莹莹,杨光义,黄伟,杨洋,毕珊榕,黎波,张显惠. 新型冠状病毒肺炎免疫抑制患者中医治疗策略[J]. 中医学报,2020,35(12):2500-2503.
WEN Xiuying, ZHANG Yingying, YANG Guangyi, HUANG Wei, YANG Yang, BI Shanrong, LI Bo, ZHANG Xianhui. Strategy of TCM in treating immune-suppressed patients with COVID-19[J]. Acta Chinese Medicine, 2020, 35(12): 2500-2503(in Chinese). |
[16] |
QI X, FAN M, HUANG N, ZHANG X, LIU J, LI X, SUN R. Saikosaponin D contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway[J]. Pharmacological Research, 2020, 160: 105 149.
|
[17] |
ZHAO X, LIU J, GE S, CHEN C, LI S, WU X, FENG X, WANG Y, CAI D. Saikosaponin A inhibits breast cancer by regulating Th1/Th2 balance[J]. Frontiers in Pharmacology, 2019, 10: 624.
|
[18] |
HU C, LI M, GUO T, WANG S, HUANG W, YANG K, LIAO Z, WANG J, ZHANG F, WANG H. Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT[J]. Phytomedicine, 2019, 58: 152 740.
|
[19] |
PONNUSAMY L, KOTHANDAN G, MANOHARAN R. Berberine and emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway[J]. Biochimica Et Biophysica Acta-molecular Basis of Disease, 2020, 1 866(11): 165 897.
|
[20] |
LI J, FENG W, LU H, WEI Y, MA S, WEI L, LIU Q, ZHAO J, WEI Q, YAO J. Artemisinin inhibits breast cancer-induced osteolysis by inhibiting osteoclast formation and breast cancer cell proliferation[J]. Journal of Cellular Physiology, 2019, 234(8): 12663-12675.
|
[21] |
LIU T, ZUO L, GUO D, CHAI X, XU J, CUI Z, WANG Z, HOU C. Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway[J]. Biomedicine & Pharmacotherapy, 2019, 120: 109 483.
|
[22] |
WANG S, WU X, TAN M, GONG J, TAN W, BIAN B, CHEN M, WANG Y J. Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy[J]. Journal of Ethnopharmacology, 2012, 140(1): 33-45.
|
[23] |
ZHONG Z, YU H, WANG S, WANG Y, CUI L. Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells[J]. Chinese Medicine, 2018, 13: 44.
|
[24] |
WANG X F, ZHOU Q M, LU Y Y, ZHANG H, HUANG S, SU S B. Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by impairing the p38 MAPK-AP1 signaling axis[J]. Expert Opinion on Therapeutic Targets, 2015, 19(5): 577-587.
|
[25] |
SHARMA G, KAR S, PALIT S, DAS P K. 18β-Glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells[J]. Journal of Cellular Physiology, 2012, 227(5): 1923-1931.
|
[26] |
SUN K J, YU W J, JI B, CHEN C B, YANG H M, DU Y Y, SONG M Y, CAI H Q, YAN F, SU R. Saikosaponin D loaded macrophage membrane-biomimetic nanoparticles target angiogenic signaling for breast cancer therapy[J]. Applied Materials Today, 2020, 18: 100 505.
|
[27] |
YU P, QIU H, WANG M, TIAN Y, ZHANG Z, SONG R. In vitro metabolism study of Saikosaponin D and its derivatives in rat liver microsomes[J]. Xenobiotica, 2017, 47(1): 11-19.
|
[28] |
YUAN B, YANG R, MA Y, ZHOU S, ZHANG X, LIU Y. A systematic review of the active Saikosaponins and extracts isolated from Radix Bupleuri and their applications[J]. Pharmaceutical Biology, 2017, 55(1): 620-635.
|
[29] |
REN M, MCGOWAN E, LI Y, ZHU X, LU X, ZHU Z, LIN Y, HE S. Saikosaponin-D: a novel anti-tumorigenic mechanism through p-STAT3/C/EBPβ-signaling suppression of COX-2 in liver cancer[J]. Frontiers in Pharmacology, 2019, 10: 623.
|
[30] |
WANG J, QI H, ZHANG X, SI W, XU F, HOU T, ZHOU H, WANG A, LI G, LIU Y, FANG Y, PIAO H L, LIANG X. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling[J]. Biomedicine & Pharmacotherapy, 2018, 108: 724-733.
|
[31] |
CHEN L, ZHANG F, KONG D, ZHU X, CHEN W, WANG A, ZHENG S. Saikosaponin D disrupts platelet-derived growth factor-b receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity[J]. ChemicoBiological Interactions, 2013, 206(1): 76-82.
|
[32] |
MORANDI A, CHIARUGI P. Metabolic implication of tumor: stroma crosstalk in breast cancer[J]. Journal of Molecular Medicine (Berlin, Germany), 2014, 92(2): 117-126.
|
[33] |
何嘉慧,王熙才,王佶,田翎含,刘源,刘馨. 肿瘤微环境与乳腺癌细胞糖代谢重编程研究进展[J]. 肿瘤学杂志,2021,27(5):359-363.
HE Jiahui, WANG Xicai, WANG Ji, TIAN Linghan, LIU Yuan, LIU Xin. Progress on metabolism reprogramming in tumor microenvironment of breast cancer[J]. Journal of Chinese Oncology, 2021, 27(5): 359-363(in Chinese). |
[34] |
徐君南,李晓睿,孙涛. 基于超高效串联质谱的氨基酸代谢组学预测晚期乳腺癌化疗反应初探[J]. 中国肿瘤临床,2017,44(24):1253-1257.
XU Junnan, LI Xiaorui, SUN Tao. A preliminary study of amino acid metabolomics using LC-MS/MS to predict the chemotherapeutic response of patients with advanced breast cancer[J]. Chinese Journal of Clinical Oncology, 2017, 44(24): 1253-1257(in Chinese). |
[35] |
SEVINSKY C J, KHAN F, KOKABEE L, DAREHSHOURI A, MADDIPATI K R, CONKLIN D S. NDRG1 regulates neutral lipid metabolism in breast cancer cells[J]. Breast Cancer Research, 2018, 20(1): 55.
|
[36] |
张楠,曹晓东,刘颖,杨冬冬,张子英. 阿霉素抗4T1乳腺癌荷瘤小鼠的免疫调控机制[J]. 生物工程学报,2021,37(7):2522-2533.
ZHANG Nan, CAO Xiaodong, LIU Ying, YANG Dongdong, ZHANG Ziying. Immunomodulatory effect of adriamycin in mouse 4T1 model of breast cancer[J]. Chinese Journal of Biotechnology, 2021, 37(7): 2522-2533(in Chinese). |
[37] |
罗燕,蒋益兰,李勇敏,谭小宁,吕元,罗吉. 柴胡皂苷D对乳腺癌MDA-MB-231细胞增殖、周期及周期相关调控因子表达的影响[J]. 中国中西医结合杂志,2019,39(5):572-576.
LUO Yan, JIANG Yilan, LI Yongmin, TAN Xiaoning, LV Yuan, LUO Ji. Effects of Saikosaponin D on the proliferation,cell cycle and the expressions of cyclins in breast cancer MDA-MB-231 cells[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2019, 39(5): 572-576(in Chinese). |
[38] |
BIJLSMA S, BOBELDIJK I, VERHEIJ E R, RAMAKER R, KOCHHAR S, MACDONALD I A, van OMMEN B, SMILDE A K. Largescale human metabolomics studies: a strategy for data (pre-) processing and validation[J]. Analytical Chemistry, 2006, 78(2): 567-574.
|
[39] |
YOON J, KIM D, KOO J. Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer[J]. Journal of Translational Medicine, 2014, 12: 149.
|
[40] |
CHA Y J, KIM D H, JUNG W H, KOO J S. Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer[J]. International Journal of Clinical and Experimental Pathology, 2014, 7(11): 7824-7833.
|
[41] |
TIAN X, WU L, JIANG M, ZHANG Z, WU R, MIAO J, LIU C, GAO S. Downregulation of GLYAT facilitates tumor growth and metastasis and poor clinical outcomes through the PI3K/AKT/Snail pathway in human breast cancer[J]. Frontiers in Oncology, 2021, 11: 641 399.
|
[42] |
BHANDARI D M, FEDOSEYENKO D, BEGLEY T P. Mechanistic studies on tryptophan lyase (NosL): identification of cyanide as a reaction product[J]. Journal of the American Chemical Society, 2018, 140(2): 542-545.
|
[43] |
HENG B, BILGIN A A, LOVEJOY D B, TAN V X, MILIOLI H H, GLUCH L, BUSTAMANTE S, SABARETNAM T, MOSCATO P, LIM C K, GUILLEMIN G J. Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression[J]. Breast Cancer Research, 2020, 22(1): 113.
|
[44] |
ALA M. The footprint of kynurenine pathway in every cancer: a new target for chemotherapy[J]. European Journal of Pharmacology, 2021, 896: 173 921.
|
[45] |
CHIARENZA A, SCARSELLI M, NOVI F, LEMPEREUR L, BERNARDINI R, CORSINI G, MAGGIO R. Apomorphine, dopamine and phenylethylamine reduce the proportion of phosphorylated insulin receptor substrate 1[J]. European Journal of Pharmacology, 2001, 433(1): 47-54.
|
[46] |
PARK J, SHIN Y, KIM T H, KIM D H, LEE A. Plasma metabolites as possible biomarkers for diagnosis of breast cancer[J]. PLoS One, 2019, 14(12): e0225129.
|
[47] |
BEETS J L, DALE M M. Inhibition of guinea-pig lymphocyte activation by histamine and histamine analogues[J]. British Journal of Pharmacology, 1979, 66(3): 365-372.
|
[48] |
GARCIA-CABALLERO M, NEUGEBAUER E, RODRIGUEZ F, NUNEZ DE CASTRO I, HEREDIA A, OOSTING E, VARA THORBECK C V. Changes in histamine synthesis, tissue content and catabolism in human breast cancer[J]. Agents and Actions, 1989, 27(1/2): 227-231.
|
[49] |
ZHU Z, QI Z, ZHANG J, XUE W, LI L, SHEN Z, LI Z, YUAN Y, WANG W, ZHAO J. Untargeted metabolomics analysis of esophageal squamous cell carcinoma discovers dysregulated metabolic pathways and potential diagnostic biomarkers[J]. Journal of Cancer, 2020, 11(13): 3944-3954.
|
[50] |
DU Y, FAN P, ZOU L, JIANG Y, GU X, YU J, ZHANG C. Serum metabolomics study of papillary thyroid carcinoma based on HPLC-Q-TOF-MS/MS[J]. Frontiers in Cell and Developmental Biology, 2021, 9: 593 510.
|