Determination of Migration of the 15 Photoinitiators from Paper-Made Packing Using Modified Polyphenylene Oxide as a Simulant by LC-MS/MS

In order to investigate the migration behavior of the PIs for the security risk assessment， the migrations of 15 photoinitiators (PIs) from paper-made packing using modified polyphenylene oxide (MPPO) as a simulant were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) MPPO, which was adsorbed the PIs migrated from paper-made packing, was extracted using acetonitrile, followed by clean-up of extract using organic phase filter. The PIs were separated in 12 min on the column of Luna PFP(2) by gradient elution with acetonitrile and water with 0.1% formic acid as mobile phase All the PIs have good linear relationship (R²>0.993) with in 0.01-0.2 mg/kg. The recoveries of 15 PIs are in the range of 70.2％-122.5％ at the spike levels of 0.01, 0.05 and 0.2 mg/kg with the relative standard deviation less than 7.5%. The limits of detection range from 0.001 to 0.021 mg/kg. The analysis of real sample shows that the method with high sensitivity and high accuracy can be applied for the determination of migration of PIs from paper-made packing.