Determination of Simvastatin by HPLC/ESI/MS and FIA/ESI MS

This paper reports a new method for determination of simvastatin in serum ,which is a regulator of blood fat.The sample serum is treated by solid phase extraction,and the recovery of the drug is about 90%.With HPLC/ESI/MS the detectable limit is 0.5ng/ml(serum).The correlation coefficient of internal calibration is r 2=0.996.For FIA/ESI/MS the coefficient of external calibration is r 2=0.986.