Chemical Ionization (CI) Application to the Confirmation of β-blockers

In the routine analysis of β blockers,when some urine were found suspicious,it was very difficult to identify the drug due to the similarities among the mass spectra of the parent drugs and many metabolites.Chemical Ionization (CI) can give more abundant mass peak on the high mass zone.The technique was applied to the confirmation of β blockers and gave a diagnostic spectrum for each compound and therefore gave definite results.