Analysis of Biphenyl-Substituted Piperazine Derivatives by ESI-MS

Three kinds of novel biphenyls modified by substituted piperazines were synthesized. These biphenyls were studied by electrospray ionization-trap mass spectrometer (ESI-MS). The result of MS indicates that the target compounds a-f form complex ions with triethyl amine through hydrogen ion M+101+H⁺ in ESI-MS. The biphenyls bearing fluorine atom also combine with Na⁺ to form molecular ion M+Na⁺ easilier than others. The result of MS² shows that the different substituent of piperazine has more effect on ESI-MSⁿ.