Study on Metabolism of Illegal Amphetamines in the Hair of Addicts

The presence of amthetamines and its metabolites in the hair of addicts was investigated using GC/MS.Methamphetamine,MDMA and fenfluramine and their metabolites-amphetamine,MDA and norfenfluramine,were found in the hair samples.Methods for the determination of amphetamines and their metabolites by GC/MS/SIM were also established for human hair samples,which had the following features:a small amount of hair (10mg)needed,low limits of detection (0.2ng/mg),and high specificity. The method has been successfully applied to routine analysis for confirmation of amphetamines abuse case.