DETECTION OF MEPERIDINE AND ITS METABOLITES IN THE HAIR OF MEPERIDINE ADDICTS

The presence of meperidine and its metabolites in The hair of meperidine addicts was investigated using GC/MS (EI, PCI). Meperidine and its three metabolites-normeperidine, n-methoxy meperidine and acetyl normeperidine, were found in hair samples from addicted subjecds. Methane for The simultaneous determination of meperidine and its metabolites by GC/MS/SIM were also established for human hair samples. After The addition of d4-meperidine as an internal Standard ho Samples weighing 5 mg were incubated in 0. 1 M HCL at 45℃ overnight and The resulting digests were e-chad with eTher,The recov- eries were greater than 80%, with coefficients of Variations (CVs) between 4.48~8.31%. The calibration curves for meperidine and normeperidine in hair were linear over a concentration of 1 to 500 mg per mg of hair, with correlation coefficients of r=0.9990 and r=0.9992, respectively. Hair Samples obtained form 60 drug addicts were analyzed using this method, and the content of meperidine and normeperidine was determined to be 103±130 and 117±143 ng/mg,respectively.Sectional analysis revealed that me- peridine was stably present in hair for at least 20 months, but normeperidine content at the level of The hair root was higher compared to the tip of the ha shaft the results also revealed that there was a correlation between the subject's drug abuse history and the distribution of drug along the for she and between the doses of meperidine and drug contents presented in hair.