Study on Non-covalent Complexes between Single strand Oligodeoxynucleotide and Flavone Compounds by Electro Spray Mass Spectrometry

Oligodeoxynucleotide from virus was selected and synthesize. Its complexes with flavone compounds were investigated by electrospray mass spectrometry. The results show that four flavones can interact with the DNA target molecule. The relative abundance of these complexes in mass spectra can assess the relative affinities of above flavones with the DNA target molecule.The above results obtained will be helpful for the screening of anti-virus drugs.