Laser Desorption Mass Spectrometry of organic Compounds

A brief review of the history of the development of Laser Desorption Mass Spectrometry of organic compounds is given. The following sections will be introduced in this paper: the principle and structure of Laser TOF-MS; the ion process of Laser Desorption/Ionization of organic compounds including matris-assisted laser desorption; main parameters and factors that effecting the analysis results; applications including comparisions of the results by using LD, FAB, FD and PDMS. The new developed matrix-assisted laser desorption of very high compound, and research results of the author's work are also introduced.