Concentration and Absorption Percentage Determination of Bifonazole Table for Vagina in Cavy

Using GC/MS SIM quantitative method with ISTD,we determinated the Bifonazole concentration in cavy's plasma,the administration doses were 6.25mg,12.5mg,25.0mg respectively;and calculated the mucous membrane absorption percentage.The results showed the concentrations of bifonazole in plasma were 16.3,23.5,27.6 ng/ml for three doses,and their absorption percent age are 0 1043,0.0752,0.0442%,respectively.