Analysis of Aconitum Alkaloids in Mongolian Medicine Garidi Wuweiwan by MALDI-TOF-MS

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used for the analysis of the aconitum alkaloids in Mongolian medicine Garidi Wuweiwan (GRDWWW). By exact molecular weight determination, 21 kinds of aconitum alkaloids including monoester-diterpenoid alklaoids, diester-diterpenoid alkaloids, and lipo-alkaloids are detected in GRDWWW. This study is expected to provide a new method for comprehensive analysis alkaloids of proprietary Chinese medicines.