新型电子电离源线型离子阱-飞行时间杂化串联质谱研究进展

江宗耀; 潘鑫渊; 贾滨; 徐国宾; 周振; 杨芃原

doi:10.7538/zpxb.2013.34.04.0193

新型电子电离源线型离子阱-飞行时间杂化串联质谱研究进展

江宗耀^1,2,
潘鑫渊^1,2,
贾滨^2,3,
徐国宾^2,3,
周振¹,
杨芃原^2,3

1.
上海大学环境与化学工程学院,上海200444
2.
教育部创新科学仪器工程中心,上海200433
3.
复旦大学化学系,上海200433

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- 刊出日期: 2013-07-19

Development of a Novel Electron Source Linear Ion Trap/Time-of-Flight Hybrid Tandem Mass Spectrometer

1.
School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
2.
Novel Scientific Instrument Engineering Centre (MOE), Fudan University, Shanghai 200433, China
3.
Department of Chemistry, Fudan University, Shanghai 200433, China

摘要

摘要: 本研究介绍了一种新型电子电离源线型离子阱-飞行时间杂化串联质谱仪，该仪器结合了线型离子阱质谱和飞行时间质谱的优点，具有较强的定性分析能力。选用全氟三丁胺(PFTBA)、四氯化碳和丙酮为测试样品对开发的仪器样机进行性能测试，包括对PFTBA碎片离子的离子分离（ISO）和碰撞诱导解离（CID）实验，以及样品同位素离子间的分离实验。测试结果表明，该仪器基本实现了离子碎裂、离子储存和串联质谱分析等功能，能够进行高精度母离子选择。本研究所开发的EI LIT-TOF质谱，在易挥发类有机化合物的结构和化学性质等研究中具有特殊的应用前景。
- 电子电离源 /
- 线型离子阱 /
- 飞行时间分析器
Abstract: This work introduces a novel electron source linear ion trap/time-of-flight hybrid tandem mass spectrometer. The system combine advantages of linear ion trap (LIT) and time-of-flight (TOF) mass spectrometry and it feathers good qualitative abilities. Standard sample of PFTBA, carbon tetrachloride and acetone is used to test the performances. The basic functions including ion trapping, isolation, collision induced dissociation (CID) and LIT-TOF interface has been proved to be excellent. Ion isolation and CID experiment of PFTBA fragment ion are demonstrated. Precise isotope ions isolation experiments shows the good selectivity performance of LIT. The EI LIT-TOF established in our laboratory can be applied to the fields of study the structure and chemical characters of volatile organic compounds (VOCs).
- electron ionization(EI) source /
- linear ion trap(LIT) /
- time of flight (TOF) analyzer

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参考文献(33)

[1]	朱建共, 季欧. 三维四极离子阱的设计[J]. 分析仪器, 1998,(4):22-26. ZHU Jiangong, JI Ou. Design of a three-dimensional quadrupole ion trap[J]. Analytical Instruments, 1998, (4):22-26 (in Chinese).
[2]	杭纬, 杨芃原, 王小如, 等. 脉冲离子阱的设计[J]. 质谱学报, 1993,15(1): 23-28. HANG Wei, YANG Pengyuan, WANG Xiaoru, et al. Designation of pulsed Ion trap[J]. Journal of Chinese Mass Spectrometry Society, 1993, 15(1): 23-28 (in Chinese).
[3]	陈焕文, 李明, 费强, 等. 小型离子阱的质量校正[J]. 分析化学, 2005,33(10):1505-1508.CHEN Huanwen, LI Ming, FEI Qiang, et al. Mass calibration of miniaturized ion trap[J]. Chinese Journal of Analytical Chemistry, 2005, 33(10): 1505-1508 (in Chinese).
[4]	陈立华, 黄荣彬, 朱海坤, 等. 激光离子源射频离子阱质谱计的研制[J]. 分析仪器, 1997,(3):8-11.CHEN Lihua, HUANG Rongbin, ZHU Haikun, et al. Development of a radio-frequency ion trap mass spectrometer with external plasma source[J]. Analytical Instruments, 1997, (3): 8-11 (in Chinese).
[5]	周春玉, 施均慧, 封跃鹏, 等. 离子阱质谱库的建立与研究[J]. 环境科学研究, 1994,7(2):7-12.ZHOU Chunyu, SHI Junhui, FENG Yuepeng, et al. Establishment and study of ITD mass spectral data base[J]. Research of Environmental Sciences, 1994, 7(2): 7-12 (in Chinese).
[6]	俞建成, 闻路红, 李晓旭, 等. 离子阱气相色谱质谱联用仪的研制和应用[J]. 仪器仪表学报, 2012,33(9):2108-2114.YU Jiancheng, WEN Luhong, LI Xiaoxu, et al. Development of an ion trap based gas chromatography mass spectrometry and its application[J]. Chinese Journal of Scientific Instrument, 2012, 33(9): 2108-2114 (in Chinese).
[7]	李晓旭, 蒋公羽, 丁力, 等. 数字化矩形离子阱质谱仪的设计及性能[J]. 分析化学, 2009,37(9):1397-1402.LI Xiaoxu, JIANG Gongyu, DING Li, et al. Design and performance of digital rectilinear ion trap mass spectrometer[J]. Chinese Journal of Analytical Chemistry, 2009, 37(9): 1397-1402 (in Chinese).
[8]	白传易, 孙琦, 顾昌鑫, 等. 矩形离子阱质量分析过程的数值模拟[J]. 真空, 2010,30(6):571-576.BAI Chuanyi, SUN Qi ,GU Changxin, et al. Modeling and simulation of mass spectrum of rectangular ion trap[J]. Chinese Journal of Vacuum Science and Technology, 2010, 30(6): 571-576 (in Chinese).
[9]	HAGER J W. A new linear ion trap mass spectrometer[J]. Rapid Communications in Mass Spectrometry, 2002,16(6):512-526.
[10]	DOUGLAS D J, FRANK A J, MAO D. Linear ion traps in mass spectrometry[J]. Mass Spectrometry Reviews, 2005,24（1):1-29.
[11]	李燕, 梁汉东, 韦妙, 等. 离子阱质谱计的研究现状及其进展[J]. 质谱学报, 2006,27(4):249-256.LI Yan, LIANG Handong, WEI Miao, et al. Introduction to ion trap mass spectrometer[J]. Journal of Chinese Mass Spectrometry Society, 2006, 27(4): 249-256 (in Chinese).
[12]	贾韦韬, 徐国宾, 姚均, 等. 高效液相色谱检测器高分辨飞行时间质谱仪的研制[J]. 质谱学报, 2006,27(3):129-134.JIA Weitao, XU Guobin, YAO Jun, et al. Development of TOF-MS used as the detector of HPLC[J]. Journal of Chinese Mass Spectrometry Society, 2006, 27(3): 129-134 (in Chinese).
[13]	杭纬, 杨华, 季欧. 一种小型反射式飞行时间质谱计[J]. 厦门大学学报, 1992,31(5):556-558. HANG Wei, YANG Hua, JI Ou. A small reflectron time of flight mass spectrometer[J]. Journal of Xiamen University(Natural Science), 1992, 31(5): 556-558 (in Chinese).
[14]	马万云, 王世亮, 田嘉禾, 等. 一种新型微区高灵敏分析装置溅射原子化激光共振电离飞行时间质谱计[J]. 质谱学报, 1990,12(1):8-15.MA Wanyun, WANG Shiliang, TIAN Jiahe, et al. A New spectrometer-sputter initiated resonance ionization time-of-flight mass spectrometer (SIRI-TOFMS)[J]. Journal of Chinese Mass Spectrometry Society, 1990, 12(1): 8-15 (in Chinese).
[15]	叶为全, 张允武, 盛六四, 等. 小型光电离反射式飞行时间质谱计[J]. 真空科学与技术学报, 1998,18(5):383-389.YE Weiquan, ZHANG Yunwu, SHENG Liusi, et al. Compact photoionization reflection time-of-flight mass spectrometer[J]. Journal of Vacuum Science and Technology, 1998, 18(5): 383-389(in Chinese).
[16]	李文莹, 黄荣彬, 郑兰荪. 双电场飞行时间质谱计的质量分辨与脉冲激光离子源飞行时间质谱计的设计[J]. 质谱学报, 1989,12(1):16-25.LI Wenyin, HUANG Rongbin, ZHENG Lansun. Mass resolution of double-field time-of-flight mass spectrometer and the design of a pulsed laser probe time-of-flight mass spectrometer[J]. Journal of Chinese Mass Spectrometry Society, 1989, 12(1): 16-15 (in Chinese).
[17]	张树东, 许明坤, 孔祥和. 飞行时间质谱峰值的漂移[J]. 光谱学与光谱分析, 2007,27(4):799-802.ZHANG Shudong, XU Mingkun, KONG Xianghe. Deviation of mass peak position in time-of-flight mass spectrum[J]. Spectroscopy and Spectral Analysis, 2007, 27(4): 799-802 (in Chinese).
[18]	张树东, 张明霞, 王艳, 等. 飞行时间质谱峰形分析[J]. 量子电子学报, 2007,24(4):438-442.ZHANG Shudong, ZHANG Mingxia, WANG Yan, et al. Analysis of the peak profile in time-of-flight mass spectrum[J]. Chinese Journal of Quantum Electronics, 2007, 24(4): 438-442 (in Chinese).
[19]	温丽华, 李海洋, 牛冬梅, 等. 飞行时间质谱的离子峰形模拟分析方法和应用[J]. 质谱学报, 2006,27(1):1-5.WEN Lihua, LI Haiyang, NIU Dongmei, et al. Simulation method of ionic peak profile in time-of-flight mass spectrum and its application[J]. Journal of Chinese Mass Spectrometry Society, 2006, 27(1): 1-5 (in Chinese).
[20]	薛坤, 窦德景, 金奇计, 等. 新式小型便携飞行时间质谱计系统[J]. 真空, 1999,(4):17-21.XUE Kun, DOU Dejing, JIN Qiji, et al. Novel portable mini-TOF MS system[J]. Vacuum, 1999,(4):17-21 (in Chinese).
[21]	王利, 李海洋, 白吉玲, 等. 飞行时间质谱中光发射电子碰撞电离过程[J]. 化学物理学报, 1998,11(1):52-56.WANG Li, LI Haiyang, BAI Jiling, et al. Laser induced photoelectron impact ionization in time-of-flight mass spectrometer[J]. Chinese Journal of Chmical Physics, 1998, 11(1): 52-56 (in Chinese).
[22]	姜杰, 费强, 金伟, 等. 小型矩形离子阱质谱仪的研制[J]. 分析化学仪器装置与实验技术, 2007,35(9):1387-1390.JIANG Jie, FEI Qiang, JIN Wei, et al. Miniature rectilinear ion trap mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2007, 35(9): 1387-1390 (in Chinese).
[23]	黄泽建, 白岗, 江游, 等. 气相色谱矩形离子阱质谱联用仪的设计与性能[J]. 分析化学仪器装置与实验技术, 2008,36(3):413-418.HUANG Zejian, BAI Gang, JIANG You, et al. Design and performance of gas chromatography-rectangular ion trap mass spectrometer[J]. Chinese Journal of Analytical Chemistry, 2008, 36(3): 413-418 (in Chinese).
[24]	黄泽建, 熊行创, 方向. 基于矩形离子阱的台式质谱仪的设计与性能[J]. 现代科学仪器, 2008,(4):50-53.HUANG Zejian, XIONG Xingchuang, FANG Xiang. Development and performance of a desktop mass spectrometer based on rectilinear ion trap[J]. Modern Scientific Instruments, 2008, (4): 50-53 (in Chinese).
[25]	DANIEL J, HENDRICKS P I, OUYANG Z, et al.Miniature monolithic rectilinear ion trap arrays by stereolithography on printed circuit board[J]. Microelectromechanical Systems, 2010,19(4): 951-960.
[26]	范茜, 金伟, 金钦汉. ESI离子阱质谱仪真空系统设计[J]. 真空, 2009,46(3):73-76.FAN Qian, JIN Wei, JIN Qinhan. Design of vacuum system for ESI Ion trap mass spectrometer[J]. Vacuum, 2009, 46(3): 73-76(in Chinese).
[27]	费强, 金伟, 姜杰, 等. 电喷雾矩形离子阱质谱仪的初步研制[J]. 现代科学仪器, 2008,(4):57-59.FEI Qiang, JIN Wei, JIANG Jie, et al. Preliminary development of electrospray ionization rectilinear ion trap mass spectrometry[J]. Modern Scientific Instruments, 2008,(4): 57-59 (in Chinese).
[28]	江游, 方向, 穰瑜, 等. 四极离子阱数字式共振激发控制技术的研发与应用[J]. 分析化学仪器装置与实验技术, 2008,36(5):715-718.JIANG You, FANG Xiang, RANG Yu, et al. Development and application of digital control technology of resonant excitation for quadrupole ion trap[J]. Chinese Journal of Analytical Chemistry, 2008, 36(5): 715-718 (in Chinese).
[29]	黄泽建, 唐晓强, 方向. 一种光电离离子阱质谱仪技术研究[J]. 质谱学报, 2009,30(2):65-69.HUANG Zejian, TANG Xiaoqiang, FANG Xiang. Development and research of a miniature photoionization ion trap mass spectrometer[J]. 2009, 30(2): 65-69(in Chinese).
[30]	黄超, 赵学红, 张建超, 等. 电子轰击源内空间电荷对其性能的影响[J]. 质谱学报, 2011,32(2):71-76.HUANG Chao, ZHAO Xuehong, ZHANG Jianchao, et al. Influence of the space charge in electron impact ion source on its performance[J]. Journal of Chinese Mass Spectrometry Society, 2011, 32(2): 71-76 (in Chinese).
[31]	黄泽建, 江游, 熊行创, 等. 基于叠型场线性离子阱的便携式质谱仪研制与应用[J]. 质谱学报, 2011,32(2):104-107.HUANG Zejian, JIANG You, XIONG Xingchuang, et al. Design and test of portable mass spectrometer based on step-like electrode linear ion trap[J]. Journal of Chinese Mass Spectrometry Society, 2011, 32(2): 104-107 (in Chinese).
[32]	高伟, 黄正旭, 郭长娟, 等. 电子轰击源垂直加速式飞行时间质谱仪的研制[J]. 质谱学报, 2008,29(4):209-217.GAO Wei, HUANG Zhengxu, GUO Changjuan, et al. Electron ionization and orthogonal acceleration time-of-flight mass spectrometer[J]. Journal of Chinese Mass Spectrometry Society, 2008, 29(4): 209-217(in Chinese).
[33]	黄超, 张建超, 汪曣, 等. 用于气相色谱-飞行时间质谱联用分析系统的电子轰击源及传输接口研制[J]. 真空科学与技术学报, 2010,30(5):524-528.HUANG Chao, ZHANG Jianchao, WANG Yan, et al. Development of electron impact source and transmission interface for analysis system of gas chromatography time-of-flight mass spectrometry[J]. Chinese Journal of Vacuum Science and Technology, 2010, 30(5): 524-528(in Chinese).

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新型电子电离源线型离子阱-飞行时间杂化串联质谱研究进展

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Development of a Novel Electron Source Linear Ion Trap/Time-of-Flight Hybrid Tandem Mass Spectrometer

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