质谱技术在G-四链体研究中的进展

谭江; 李亦舟; 周江

doi:10.7538/zpxb.2021.0111

质谱技术在G-四链体研究中的进展

1.
重庆大学药学院,重庆400030
2.
北京大学化学与分子工程学院,北京100871

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出版历程
- 刊出日期: 2021-09-19

Progress of Study on G-quadruplex by Mass Spectrometry

1.
School of Pharmacy, Chongqing University, Chongqing 400030, China
2.
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

摘要

摘要: G-四链体是通过富含鸟嘌呤的DNA或RNA序列形成的非典型核酸二级结构，存在于多种生物系统中，发挥着调控基因表达的作用，目前已成为潜在的药物治疗靶点。质谱技术因其灵敏度高、准确度高、样品消耗少等特点，成为研究G-四链体结构和G-四链体/小分子配体结合的强大工具。本文将对G-四链体的形成、结构、稳定化和碰撞解离行为、小分子识别及结合亲和力、化学计量比的质谱研究，RNA G-四链体结构特征的质谱研究，以及其他用于G四链体构象分析的质谱技术进行综述。
- 质谱法 /
- G-四链体 /
- 核酸 /
- 配体分子
Abstract: The G-quadruplex is an atypical secondary structure of nucleic acid formed by guanine-rich sequences, which exists in a variety of biological systems and plays an important role in regulating gene expression. So it has become a potential drug therapy target. Mass spectrometry technology is widely used in the study of G-quadruplexes because of its high sensitivity, high accuracy and low sample consumption. It has become a powerful tool for studying the structures of Gquadruplexes and the binding of G-quadruplexes with small molecule ligands. Mass spectrometry detection of G-quadruplex formation, binding affinity and stoichiometry, stabilization and collision dissociation behavior of G-quadruplex DNA, progress of MS research on RNA G-quadruplex, and other mass spectrometric techniques for conformational analysis of G-quadruplex would be reviewed in this study.
- mass spectrometry /
- G-quadruplex /
- nucleic acid /
- ligand

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参考文献(107)

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质谱技术在G-四链体研究中的进展

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Progress of Study on G-quadruplex by Mass Spectrometry

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