Abstract: The basic principle and the newly developments of accelerator mass spectrometry (AMS) were presented in this review. AMS is a kind of high-energy mass spectrometry which combines accelerator and ion detector. It overcomes restrictions of interference derived from molecule and isobar. It has been applied in the fields of geology, oceanography, archaeology, and environmental science. In the future, the research of AMS tend toward miniaturization and ultra high sensitivity and it will become one of the most meaningful technology.