Abstract:
Harmaine has good pharmacological activities, such as antibacterial, anti-tumor, hypoglycemic, and so on. However, harmine also has strong neurotoxicity. Exploring the neurotoxicity mechanism of harmine can help to improve the clinical application and obtain high-efficiency and low-toxic compounds in the later study. UPLC-QTOF MS technology was applied to explore the neurotoxic mechanism of harmine from the changes in Caenorhabditis elegans metabolites at different time points after administration. The results showed that harmine could mainly affect the purine metabolic pathways and amino acid-related metabolic pathways of nematodes. The neurotoxicity of harmine might be related to energy metabolism. The study can provide reference to the research of neurotoxicity of total alkaloids in Camellia pueracea.
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