含高阶场成分的四极杆电极系统及其性质

王岳东; 肖育; 陈末华; 王冠军; 丁传凡

doi:10.7538/zpxb.youxian.2014.0010

含高阶场成分的四极杆电极系统及其性质

复旦大学化学系激光化学研究所,上海200433

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- 刊出日期: 2014-05-19

The Quadrupole Rod System with Added Higher Order Fields

Department of Chemistry and Laser Chemistry Institute, Fudan University, Shanghai 200433, China

摘要

摘要: 由4根柱状电极组成的四极杆电极系统在射频电源的作用下主要产生以四极电场为主的电场分布。四极电场可以用于离子质量分析、离子存储和离子传输等。理论分析表明，只有用4根双曲面电极组成四极杆电极系统时，才会产生纯四极场分布；在其他情况下，除四极电场外，还可能会产生六极、八极、十二极、二十极等高阶电场成分。本研究用数值计算的方法，分析了用4根不同直径的圆柱形电极组成的四极杆电极系统的电场分布情况和作为质量分析器时的性能。结果表明：当用3根相等直径和1根较大直径的圆柱形电极组成四极杆电极系统时，可以产生除四极电场外的高阶电场分布，其高阶场成分主要有六极场（A₃）、八极场（A₄）、十极场（A₅）、十二极场（A₆）、二十极电场（A₁₀）等；各种高阶场的含量可以通过改变圆柱形电极的直径，或使具有较大直径的圆柱形电极偏转一定的角度加以调节；当四极电场中含有一定量的高阶电场时，仍可获得较好的质量分辨。含高阶场的四极杆电极系统具有较高的离子传输效率和更好的离子串联质谱分析能力，具有潜在的实用价值。
- 四极杆电极系统 /
- 高阶电场 /
- 质量分辨 /
- 质谱性能
Abstract: When supplied with radio-frequency power, quadrupole rodset with four cylindrical electrodes mainly produces quadrupole electric field. Quadrupole field can be used for the ion mass analysis, ion storage and ion transmission etc. Theoretical analysis shows that the pure quadrupole field can only be produced by four hyperbolic cross sectional electrodes. In other cases, higher order fields will be produced, such as hexapole, octopole, decapole, dodecapole and so on. Electric field distribution and the performance of the quadrupole rod system which were composed of four cylindrical rods with different diameters were investigated with numerical calculation. The results show that some higher order fields, such as A₃, A₄, A₅, A₆, A₁₀ can be added to the quadrupole field when the quadrupole rod system is composed of three identical rods and one bigger rod, and the quantity of each field can be adjusted by changing the diameters of the rods, or rotating the bigger rod with some angle. The quadrupole rod system with added higher order fields can still has good mass resolution. And it could also have higher ion transmission efficiency and better tandem mass spectrometry analysis ability, the quadrupole rod system given in this paper will have potential practical value.
- quadrupole mass filter /
- higher order field /
- mass resolution /
- mass spectrometry performance

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参考文献(25)

[1]	AEBERSOLD R, MANN M. Mass spectrometry-based proteomics[J]. Nature, 2003, 422: 198-207.
[2]	KASSEL D B. Combinatorial chemistry and mass spectrometry in the 21st century drug discovery laboratory[J]. Chem Rev, 2001, 101(2): 255-268.
[3]	RICHIARDSON S D. Mass spectrometry in environmental sciences[J]. Chem Rev, 2001, 101(2): 211-254.
[4]	HOFSTADLER S A , GRIFFEY R H. Analysis of noncovalent complexes of DNA and RNA by mass spectrometry[J]. Chem Rev, 2001, 101(2): 377-390.
[5]	MANN M, HENDRICKSON R C, PANDEY A. Analysis of proteins and proteomes by mass spectrometry[J]. Annu Rev Biochem, 2001, 70: 437-473.
[6]	DAWSON P H. Quadrupole mass spectrometry and its applications[M]. Elservier: Amsterdam, 1976.
[7]	PAUL W, REINHARD H P, VONZAHN U. Das elektrische massenfilter als massenspektrometer und isotopentrenner[J]. Zeitschrift Fur Physik, 1958, 152(2): 143-182.
[8]	DAYSON I E, SHOEMAKER F C, MOZLEY R F. The measurement of 2-dimensional fields 2.study of a quadrupole magnet[J]. Rev Sci Instru, 1954, 25(5): 485-489.
[9]	DENISON D R. Operating parameters of a quadr-upole in a grounded cylindrical housing[J]. J Vac Sci Technol, 1971, 8（1）: 266-269.
[10]	DAWSON P H, WHETTEH N R. Non-linear resonances in quadrupole mass spectrometers due to imperfect fields: II. the quadrupole mass filter and the monopole mass spectrometer[J]. Int J Mass Spectrom Ion Processes, 1969, 3（1/2）: 1-12.
[11]	GIBSON J R, TAYLOR S. Prediction of quadrupole mass filter performance for hyperbolic and circular cross section electrodes[J]. Rapid Commun Mass Spectrom, 2000, 14: 1669-1673.
[12]	GIBSON J R, TAYLOR S. Numerrical investigation of the effect of electrode size on the behavior of quadrupole mass filters[J]. Rapid Commun Mass Spectrom, 2001, 15（20）: 1960-1964.
[13]	DOUGLAS D J, GLEBOVA T A, KONENKOV N V, et al. Spatial harmonics of the field in a quadrupole mass filter with circular electrodes[J]. Technical Physics, 1999, 44（10）: 1215-1219.
[14]	SUDAKOV M, DOUGLAS D J. Linear quadrupoles with added octopole fields[J]. Rapid Commun Mass Spectrom, 2003, 17（20）: 2290-2294.
[15]	DING C F, KONENKOV N V, DOUGLAS D J. Quadrupole mass filters with octople fields[J]. Rapid Commun Mass Spectrom, 2003, 17（22）: 2495-2502.
[16]	DOUGLAS D J, KONENKOV N V. Rapid commun. Influence of the 6th and 10th spatial harmonics on the peak shape of a quadrupole mass filter with round rods[J]. Rapid Commun Mass Spectrom, 2002, 16: 1425-1431.
[17]	肖育, 丁传凡. 十极场成分对四极质谱性能的影响[J]. 质谱学报，2010， 31（5）： 270-275. XIAO Yu, DING Chuanfan. The effect of higher order multipole fields on the property of quadrupole mass filter[J]. Journal of Chinese Mass Spectrometry Society, 2010, 31(5):270-275（in Chinese）.
[18]	DU Z H, DOUGLAS D J, GLEBOVA T, et al. Peak structure with a quadrupole mass filter operated in the third stability region[J]. Int J Mass Spectrom, 2000, 197（1/2/3）: 113-121.
[19]	DING L, SUDAKOV M, BRANCIA F L, et al. A digital ion trap mass spectrometer coupled with atmospheric pressure ion sources[J]. J Mass Spectrom, 2004, 39（5）: 471-484.
[20]	SUDAKOV M, KONENKOV N V, DOUGLAS D J, et al. Excitation frequencies of ions confined in a quadrupole field with quadrupole excitation[J]. J Am Soc Mass Spectrom, 2000, 11（1）: 10-18.
[21]	REUBEN A J, SMITH G B, MOSS P, et al.Ion trajectories in exactly determined quadrupole fields[J]. Int J Mass Spectrom Ion Processes, 1996, 154（1/2）: 43-59.
[22]	SHERETOV E P, GUROV V S, KOLOTILIN B I. Modulation parametric resonances and their influence on stability diagram structure[J]. Int J Mass Spectrom, 1999, 184（2/3）: 207-216.
[23]	DU Z H, DOUGLAS D J. Peak splitting with a quadrupole mass filter operated in the second stability region[J]. J Am Soc Mass Spectrom, 1999, 10（12）: 1263-1270.
[24]	TITOV V V. Detailed study of the quadrupole mass-analyzer operating within the first, second, and the third (intermediate) stability regions.Ⅱ.Transmission and resolution[J]. J Am Soc Mass Spectrom, 1998, 9（1）: 70-87.
[25]	TITOV V V. Detailed study of the quadrupole mass-analyzer operating within the first, second, and the third (intermediate) stability regions.Ⅰ.Transmission and resolution[J]. J Am Soc Mass Spectrom, 1998, 9（1）: 50-69.

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含高阶场成分的四极杆电极系统及其性质

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The Quadrupole Rod System with Added Higher Order Fields

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