LC-MS/MS法测定纸质包装材料中15种光引发剂向改性聚苯醚模拟物的迁移量

Determination of Migration of the 15 Photoinitiators from Paper-Made Packing Using Modified Polyphenylene Oxide as a Simulant by LC-MS/MS

  • 摘要: 为了考察光引发剂的迁移特性,评估安全风险,建立了一种基于液相色谱串联质谱(LC-MS/MS)分析纸质包装材料中15种光引发剂向改性聚苯醚(MPPO)模拟物迁移量的方法。纸质包装材料中迁移出的被分析物被MPPO吸附后用乙腈萃取,萃取液经有机滤膜过滤后,采用乙腈和0.1%甲酸水溶液作为流动相进行梯度洗脱,Luna PFP(2)色谱柱(150 mm×4.6 mm×3 μm)分离,串联质谱法分析,外标法定量。通过对色谱条件优化,15种光引发剂在12 min内可实现有效分离,且目标分析物在0.01~0.2 mg/kg范围内线性关系良好,线性相关系数R2>0.993。3个加标水平(0.01、0.05和0.2 mg/kg)的回收率在70.2%~122.5%之间,相对标准偏差(RSD)小于7.5%,检出限(LOD)为0.001~0.021 mg/kg。实际样品的分析结果表明,该方法的检出限低、测定结果准确,可用于纸质包装材料中15种光引发剂向改性聚苯醚模拟物迁移量的检测。

     

    Abstract: In order to investigate the migration behavior of the PIs for the security risk assessment, the migrations of 15 photoinitiators (PIs) from paper-made packing using modified polyphenylene oxide (MPPO) as a simulant were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) MPPO, which was adsorbed the PIs migrated from paper-made packing, was extracted using acetonitrile, followed by clean-up of extract using organic phase filter. The PIs were separated in 12 min on the column of Luna PFP(2) by gradient elution with acetonitrile and water with 0.1% formic acid as mobile phase All the PIs have good linear relationship (R2>0.993) with in 0.01-0.2 mg/kg. The recoveries of 15 PIs are in the range of 70.2%-122.5% at the spike levels of 0.01, 0.05 and 0.2 mg/kg with the relative standard deviation less than 7.5%. The limits of detection range from 0.001 to 0.021 mg/kg. The analysis of real sample shows that the method with high sensitivity and high accuracy can be applied for the determination of migration of PIs from paper-made packing.

     

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