苯环壬酯及其代谢物的电子轰击和电喷雾电离质谱分析

Analysis of Phencynonate by Electron Ionization Mass Spectrometry and Electron Spray Ionization Mass Spectrometry

摘要: 采用电子轰击质谱（EI-MS）、电喷雾电离质谱（ESI-MS）两种技术分别对苯环壬酯结构和裂解途径进行了研究。采用ESI-MS获得m/z 358M+H⁺、156、342等质谱峰，并对大鼠尿中的代谢产物结构进行了确证；采用EI-MS获得m/z 357M^＋、138、175、154、215等质谱峰，并解释了其中的主要特征碎片离子。

Abstract: Electron ionization mass spectrometry (EI-MS) and electron spray ionization mass spectrometry (ESI-MS) were used for the elucidations of the structure and fragmentation pathway of phencynonate (PC). The guasi-molecular ion peak m/z 358M+H⁺, and m/z 156, 342 were detected by ESI-MS, the metabolite of PC in rat urine were also detected and the fragmentation pathway of PC was descripted; m/z 357M⁺ and m/z 138, 175, 154, 215 were detected by EI-MS. Further more, the fragmentation pathway of PC was also explained. The results provided a valuable information for the investigation and development of drugs similar to PC.