Abstract: An analytical method based on microwave digestion and ICP-MS detection was developed for the determination of lead in lipsticks. The conditions of the digestion were optimized by different mix-acid and sample weight, 0.2 g sample and a mixture of HNO₃＋HF＋H₂O₂ was found available. Its accuracy and precision were evaluated by GBW(E)090028 and two lipsticks. The results indicated that microwave-ICP-MS is accurate, sensitive and short of analytical cycle, which can meet the demand for the determining lead in lipsticks.