Abstract: A review is presented on the developments of remote site fragmentation in gas phase. Some proposal mechanisms, methods of estimating internal energy and its applications in the analysis of some long chain organic compounds are discussed. Remote site fragmentations in very low collision energy (0～10eV) are observed as well as in high collision energy (6KeV～8KeV) and further investigations are suggested. This type of fragmentation has become an excellent instrumental analysis method for the structural determinaton of some modified organic compounds.