同位素稀释多接收电感耦合等离子体质谱法测定血铅

Determination of Lead in Blood by Isotope Dilution Multicollector Inductively Coupled Plasma Mass Spectrometry

摘要: 采用同位素稀释多接收电感耦合等离子体质谱（ID-MC-ICP-MS）法测定血铅。运用同位素稀释法测得整个实验的流程空白Pb的浓度平均值为5.6 ng。对SRM 955b level 1和SRM 955b level 3标准血样进行分析，测得血样浓度分别为40.2、207.8 μg•L^-1，测定值落在血样参考值范围之内，证明该方法有效、可靠。利用建立的血铅分析方法，参加了络合型血铅标准物质的定值，得到3种血铅标准样中铅的浓度分别为（102.7±5.5）、（181.7±4.0）、（304.1±3.9） μg•L^-1。

Abstract: A method for determination of trace Pb in blood was established by isotope dilution multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS). The average Pb analytical blank obtained in this laboratory is 5.6 ng. A Nist standard reference materials of (SRM) 955b level 1 and (SRM) 955b level 3 were used to evaluate the accuracy of Pb concentration in blood. The measured values are 40.2 and 207.8 μg•L^-1 respecetively, in good agreement with their certified value. The established method was used for determination the Pb concentration of three blood samples, the uncertainty of measurement results were also analyzed and evaluated . The Pb concentration of three blood samples are （102.7±5.5）, （181.7±4.0） and （304.1±3.9） μg•L^-1.