Abstract: In this article the recent work done by our group have been introduced, which are mass spectrometry technique of the trace level Plutonium isotopic abundance ratio for environmental sample, the determining of individual particle consisting of uranium and mass spectrometry measurement of uranium isotopic ratio for swipe sample. Meanwhile, here narrates the application of these mass spectrometry analysis techniques in the field of against the international nuclear terrorism such as the identification and attribution for intercepted nuclear materials , environment sample of post-detonation analysis etc.