液相色谱-串联质谱法测定牛奶中舒巴坦和他唑巴坦

Determination of Salbactam and Tazobactam in Milk by LC-MS/MS

Abstract: A triple quadrupole liquid chromatography tandem mass spectrometry method is presented for the quantitative determination and confirmation of salbactam and tazobactam, the inhibitors of β-lactamase in milk. Milk was extracted with methanol, and the extracts were analyzed by LC-MS/MS in negative mode. The LOQs of salbactam and tazobactam in milk are 10 μg•L^－1 and 100 μg•L^－1, respectively.