Abstract: An HPLC-APPI（+）MS-MS method was developed by solid phase extraction decontamination for the residue determination of PAHs. The sample was extracted by the methyl alcohol after comminution and operating for decontamination by C₁₈ cartridges. Samples were detected by a gradient elution flowing with a APPI positive mode detector at MRM(naphthalene m/z 128， acenaphthylene m/z 152， acenaphthene m/z 154， fluorene m/z 166， phenanthrene m/z 178， anthracene m/z 178， fluoranthene m/z 202， pyrene m/z 202， benz(a)anthracene m/z 228， chrysene m/z 228， benzo(b)fluoranthene m/z 252， benzo(k)fluoranthene m/z 252， benzo(a)pyrene m/z 252， benzo(g,h,I)perylene m/z 276， indeno(1,2,3,c,d)pyrene m/z 276， dibenz(a,h)anthracene m/z 278). The LOQs (S/N＞10)of 16 PAHs residues in the negative meat sample are 0.10.2 mg•kg^-1. The recovery values is 72.0%-89.6%. The response for 16 PAHS is linear in the range of 0.1-10.0 μg•L^-1, and the correlation coefficient is excellent(r: 0.993 2-0.999 2).