Abstract: The correlative characteristics between lead and other elements in the blood of rats exposed to lead were studied. Totally 75 healthy 4-week-old male Sprague-Dawley rats (SD rats) were randomly divided into 25 groups. Doses of lead acetate were different in terms of groups respectively. One rat each group was selected randomly at the beginning of the experiment stage of 40, 80, 120 days. Under ether anesthesia, blood was obtained from femoral artery. Concentrations of 24 elements in the blood were determined by inductively coupled plasma mass spectrometry (ICP-MS)， and correlation analysis was done between Pb and other elements. The results indicate that the relation between exposure doses and concentration of blood lead are different at different exposure stages. With the increase of the exposure time the concentration of blood lead is rising. However, at the exposure dose of 5-70 mg•kg^-1，the concentration of blood lead in the 80-day exposure group is higher than 120-day exposure group. Correlation of concentration of blood lead and other elements changes at different exposure cycle.