Abstract: The Latest Advance in Using Isotope Mass Spectrometry to Solve Medical Science ProblemsLuo Kewen(Institute of Karst Geology,Guilin 541004,China)Abstract:The test for the detection of Helicobacter Pylon(HP) infection using the isotope 13C, 14C and 15N as a tracer has grealy advanced in recent years. It makes a new way for using isotope to solve medical science problems. The 13C -urea breath test has advantages such as non-invasive,non-radioactive and no pollution. It has no special demand to patients. The method is convenient. The correction rate of diagnosis has been more than 93%. The 14C-urea breath test has a very high sensitivity. Its correction rate has been more than 96%, but 14C has light radiation,it had better not be used in children and pregnant woman. The 15N-urea excretion test is a simple,high sensitive,non-invasive and non-radioactive test. Its correction rate is 96%. It can be popularized in any area which have certain conditions.Keywords: Helicobacter Pylori(HP),breath tests, excretion tests